Erysk-TargetDisk

Molecular analysis of biomarkers of early Mycosis fungoides for support in challenging cases using FFPE skin samples. Discover the latest molecular insights in MF research!

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Measurement of biomarkers beyond morphology.

Support the characterization of MF from benign inflammatory in challenging cases.

Early-stage Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), often mimics eczema and psoriasis, clinically and histologically. Clinical presentation and histopathology often overlap with benign inflammatory dermatoses, making a clear distinction difficult, even for experienced specialists.

In routine practice, the diagnostic pathway typically begins with clinical suspicion, followed by skin biopsy and histopathological assessment. In many cases, however, the uncertainty persists until the disease has progressed to the point where it can no longer be treated as effectively as it could have been in the early stages. This is where molecular information can add value.

The Erysk-TargetDisk (RUO) enables the measurement of MF-associated gene expression biomarkers LCK and HOMER1 from standard FFPE skin samples. This provides an additional layer of biological insight to support the characterization of challenging cases.

Adding objective insight where routine diagnostics reach their limits.

Why early MF remains difficult to diagnose?

  • Clinical and histological overlap with eczema and psoriasis
  • Limited specificity in early disease stages
  • Frequent need for repeated biopsies
  • Diagnostic delays in routine practice

A molecular approach to support your workflow

The Erysk-TargetDisk (RUO) measures gene expression biomarkers such as LCK and HOMER1 from FFPE samples. These markers are associated with MF and provide insight into underlying disease biology and help to describe early mycosis fungoides from benign dermatoses like Psoriasis or eczema in challenging cases.

Designed for dermatopathology workflows

KEY BENEFITS

Erysk-TargetDisk provides a deeper insight into the biological processes of the skin and provides additional context that can help advance clinical methodology development (research use only).

  • Tissue type: FFPE skin samples 
  • Molecular support in unclear cases: Measurement of biomarkers of early mycosis fungoides 
  • Based on validated biomarkers (LCK, HOMER1)
  • Seamless integration: Compatible with the fully automated Dermagnostix Analyzer. 
  • Supports the analysis of MF vs benign dermatoses
  • Adds objective molecular information to histology
  • Minimal hands-on time (<3 minutes) 
  • Results available within 2 hours

Scientifically validated biomarkers

A gene expression–based molecular classifier was developed to differentiate early Mycosis fungoides (MF), a cutaneous T-cell lymphoma (CTCL), from eczema and psoriasis.

Key findings:

  • Clear biological differentiation based on LCK and HOMER1
  • 91% sensitivity and 94% specificity
  • Consistent performance across international cohorts
  • Case analyses showed that molecular testing enabled earlier detection of MF than conventional histopathology, supporting improved clinical decision-making. 

These results highlight the value of adding molecular information in diagnostically challenging cases.

Discover how the Erysk-TargetDisk (RUO) can support your workflow in challenging cases

Dermagnostix Labor

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